Anti-GRK 2 / ADRBK1 Antibody

This mouse monoclonal antibody specifically recognizes GRK 2 (G protein-coupled receptor kinase 2), a serine/threonine kinase encoded by the ADRBK1 gene that phosphorylates activated G protein-coupled receptors and drives beta-adrenergic receptor desensitization. From Antibodies.com, the reagent is supplied as a purified IgG preparation in 100 µl vials, formulated in 0.1 M Tris-Glycine buffer (pH 7.4) with 150 mM NaCl, 0.2% sodium azide as preservative, and 50% glycerol. It is unconjugated and validated for Western blot detection of the ~80 kDa kinase in both human and mouse samples. Researchers studying GPCR signalling, beta-adrenergic receptor regulation, cardiac signalling pathways, and receptor desensitization mechanisms rely on this reagent to probe endogenous GRK 2 expression in cell and tissue lysates. Store the vial frozen, protect from light, and aliquot upon arrival to limit freeze-thaw cycles and preserve binding activity.