Anti-GRIN2B Antibody

GRIN2B (glutamate ionotropic receptor NMDA-type subunit 2B, also called NR2B) is the obligatory regulatory subunit of the heteromeric N-methyl-D-aspartate receptor, the principal excitatory glutamate-gated calcium channel at central nervous system synapses. Researchers investigating synaptic plasticity, long-term potentiation, and the molecular basis of learning and memory rely on validated GRIN2B detection reagents to localize and quantify subunit expression across hippocampal, cortical, and cerebellar tissue preparations.

This polyclonal reagent, distributed by Antibodies.com, is raised in rabbit and supplied as an unconjugated IgG preparation in a 100 µl volume, supporting multiple western blot experiments on mouse-derived samples. The polyclonal profile expands epitope coverage across the intracellular C-terminal region of NR2B, which is useful for probing phosphorylation states linked to postsynaptic density anchoring. Investigators working with GRIN2B variants associated with neurodevelopmental disorders, including early-onset epilepsy, intellectual disability, and autism spectrum phenotypes, routinely use mouse-reactive antibodies to characterize knock-in and knockout models.

Working aliquots help preserve reagent activity across repeated freeze-thaw cycles; the unconjugated format enables flexible pairing with HRP- or fluorophore-conjugated secondary antibodies for chemiluminescent or near-infrared western blot detection in neuroscience and neuropharmacology laboratories.