Anti-GRIK2 Antibody

The kainate receptor subunit GluK2 is encoded by the GRIK2 gene and serves as a key ionotropic glutamate receptor component in central nervous system signaling. This rabbit polyclonal reagent from Antibodies.com is raised against GRIK2 and supplied as an unconjugated preparation in a 100 µl vial, validated for Western blot, immunohistochemistry, and immunofluorescence workflows across human, mouse, and rat sample types.

GluK2-containing kainate receptors are widely investigated in neurobiology research, with documented roles in synaptic transmission, neuronal excitability, and plasticity. Studies link GRIK2 to neurodevelopmental conditions including intellectual disability and autism spectrum disorder, as well as to epilepsy, schizophrenia, and bipolar disorder, making reliable detection tools valuable for both basic neuroscience and translational programs. The polyclonal antibody format allows recognition of multiple epitopes on the target, which can improve signal consistency in tissue sections and lysates compared to monoclonal alternatives.

For best results, aliquot the antibody and store frozen at -20°C for long-term preservation, avoiding repeated freeze-thaw cycles to maintain binding activity. The unconjugated format provides flexibility for users who wish to couple the reagent to their preferred fluorophore, enzyme, or biotin label in custom assay development. Researchers commonly apply this reagent to neuronal cell cultures, brain tissue sections, and recombinant protein preparations to map GluK2 distribution and abundance in both in vitro and disease-modeling studies.