Anti-GREM2 Antibody

This unconjugated rabbit polyclonal antibody recognizes Gremlin 2 (GREM2), a secreted BMP antagonist belonging to the DAN family, and is supplied by Antibodies.com at 1 mg/ml in phosphate buffered saline containing 0.05% sodium azide at pH approximately 7.3. The 100 µl vial supports typical western blot campaigns where GREM2 abundance is tracked across multiple sample sets.

GREM2, also known as PRDC (Protein Related to DAN and Cerberus), modulates BMP signaling in extracellular compartments and has documented roles in osteoblast differentiation, tooth morphogenesis, renal pathology, and tumor-stroma crosstalk. The reagent has been validated for human, mouse, and rat samples, enabling cross-species comparisons in animal models and human tissue cohorts. Common western blot inputs include transfected cell lysates, tissue homogenates, and conditioned medium from cells that secrete the protein.

Because the polyclonal host recognizes multiple epitopes on GREM2, the antibody is well suited to studies probing cleavage products, secreted versus intracellular pools, or post-translational modifications. The 0.05% sodium azide preservative means the reagent is appropriate for lysate-based detection only and should be kept away from live-cell workflows. For day-to-day handling, equilibrate the vial to room temperature briefly before withdrawal, then return it to refrigeration; aliquoting avoids repeated freeze-thaw stress on the stock.

This research-use-only reagent fits laboratories investigating BMP pathway biology, skeletal or dental development, fibrotic disease mechanisms, and cancer signaling networks where Gremlin 2 function is of interest.