Anti-GRB7 Antibody

Raised in rabbit against Growth Factor Receptor Bound protein 7 (GRB7), this unconjugated polyclonal primary antibody from Antibodies.com is supplied as 100 µl of liquid antiserum. It is validated for Western blot and immunohistochemistry on human, mouse, and rat specimens, supporting cross-species studies of receptor tyrosine kinase signaling.

GRB7 is an SH2-domain adaptor protein frequently investigated in growth factor pathways, especially HER2/ErbB2-driven cascades implicated in breast cancer progression. The GRB7 locus is commonly co-amplified with HER2 on chromosome 17q12, and the encoded protein contributes to tumor cell migration, proliferation, and metastatic signaling. Researchers apply this reagent to whole-cell or tissue lysates by Western blot and to fixed sections by immunohistochemistry to map GRB7 localization in normal and disease models.

Provided in a single-use vial, the antiserum should be aliquoted upon first use to limit freeze-thaw cycles and refrigerated for routine storage. Working dilutions should be optimized empirically for each assay, and the unconjugated format allows flexible pairing with the secondary reporter of choice.