Anti-GRB7 Antibody

Targeting Growth Factor Receptor Bound protein 7 (GRB7), this unconjugated polyclonal primary antibody from Antibodies.com is raised in rabbit and supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, shipped as a 100 µl vial ready for immunodetection workflows.

GRB7 is an SH2-domain adapter that mediates downstream signaling from receptor tyrosine kinases including HER2/ERBB2 and focal adhesion kinase, influencing cell migration, proliferation, and invasive behavior. Validated for Western blot and immunohistochemistry, the reagent shows reactivity against human, mouse, and rat samples, supporting cross-species studies in cancer biology and receptor pathway research, particularly in breast cancer models and other tumor contexts where GRB7 amplification or overexpression is implicated.

For immunoblotting, the antibody can be combined with HRP- or fluorophore-conjugated secondary reagents and chemiluminescent or chromogenic detection systems. Paraffin-embedded or frozen tissue sections can be processed for IHC using standard antigen retrieval and blocking protocols. Storage at -20 °C in single-use aliquots is recommended to limit freeze-thaw cycles and preserve binding activity. The polyclonal format provides epitope diversity that supports recognition of denatured target in Western blot as well as native configurations relevant to tissue staining.