Anti-GRAP2 Antibody

The GRAP2 adaptor (GRB2-related adaptor protein 2, ~41 kDa) couples activated T cell and B cell receptors to downstream signaling cascades through its SH2 and SH3 protein interaction modules. This unconjugated rabbit polyclonal IgG reagent from Antibodies.com was raised against recombinant GRAP2 and is validated for Western blot detection of endogenous protein in human and mouse sample lysates.

Each vial contains 200 µl of liquid antiserum, sufficient for multiple immunoblot experiments. For best results, store aliquots at -20 °C, avoid repeated freeze-thaw cycles, and keep working stocks refrigerated at 4 °C. The polyclonal format recognizes multiple epitopes across the target, which is helpful when probing potentially truncated or post-translationally modified GRAP2 species in tissues such as thymus, spleen, and lymph node.

Typical research uses include characterization of T cell receptor signaling complexes, mapping GRAP2 association with SLP-76 and other adaptors during immunological synapse formation, and assessment of GRAP2 expression across lymphocyte subsets during development, activation, or in disease contexts where this adaptor has been implicated. The unconjugated format allows pairing with HRP-, fluorophore-, or biotin-conjugated secondary antibodies chosen by the researcher.