Anti-Granzyme K Antibody

The Granzyme K target is a chymotrypsin-like serine protease stored in the cytolytic granules of cytotoxic T lymphocytes and natural killer cells. Unlike granzyme B, which drives caspase-dependent apoptosis, granzyme K triggers a distinct caspase-independent pathway that has been linked to gasdermin B cleavage and pro-inflammatory cell death. This polyclonal reagent from Antibodies.com is raised in rabbit hosts and supplied as 100 µl of unconjugated antibody, validated for western blot, immunohistochemistry, immunofluorescence, and ELISA workflows with reactivity confirmed against human, mouse, and rat samples. Investigators studying cytotoxic granule release, NK cell effector function, or chronic inflammatory disease models can use it to probe GzmK expression at the protein level across tissue sections and cell lysates, supporting studies of immune-mediated cytotoxicity and granule exocytosis pathways.