Anti-GPR68 Antibody

Raised in rabbit against the human proton-sensing G-protein coupled receptor GPR68, also known as OGR1 (ovarian cancer G-protein-coupled receptor 1), this polyclonal antibody targets a receptor that converts acidic extracellular pH into intracellular signals via Gq/11 and Gs pathways. Published work links the receptor to osteoclast differentiation, vascular smooth muscle biology, and the tumor microenvironment, where local acidosis drives downstream cellular responses relevant to inflammation, bone remodeling, and cancer biology.

From Antibodies.com, the reagent is supplied as 100 µl of unconjugated polyclonal antiserum at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol. It is validated for Western blot and immunohistochemistry on human samples, supporting studies of acid-sensing GPCR signaling, bone resorption models, and oncology research that examines receptor expression in tissue sections or whole-cell lysates.

The vial should be refrigerated and protected from light; aliquot before use to limit freeze-thaw cycles and preserve binding activity across repeated experiments.