Anti-GPR56 Antibody

The Antibodies.com polyclonal antibody targets GPR56, a member of the adhesion G protein-coupled receptor family also designated ADGRG1. Produced in rabbit and supplied as an unconjugated reagent, this antibody is validated for Western blot and immunofluorescence workflows on human samples, with ELISA compatibility noted in the supplier datasheet. Each vial contains 100 µl of polyclonal antiserum for routine immunodetection of endogenous receptor levels in cell lysates and tissue sections.

GPR56 is widely studied in the context of cortical development, where loss-of-function mutations are linked to bilateral frontoparietal polymicrogyria, and in oncology research examining melanoma and glioma cell invasion. The extracellular region of GPR56 contains a long N-terminal domain that binds tissue-specific ligands, including collagen III in the developing brain, making the receptor a target of interest for studies of cell adhesion, neuronal migration, and tumor microenvironment signaling. Researchers apply this reagent to characterize receptor expression across patient-derived samples and engineered cell lines.

For best results, aliquot upon arrival to limit freeze-thaw cycles, store refrigerated, and protect from light. Intended for research use only.