Anti-GPR171 Antibody

Primary antibodies targeting G protein-coupled receptors enable researchers to investigate receptor expression and distribution across human tissues. This polyclonal antibody from Antibodies.com specifically recognizes GPR171, an orphan GPCR implicated in feeding behavior, energy homeostasis, and pain modulation through its interaction with the BigLEN neuropeptide ligand derived from proSAAS. Raised in rabbit and supplied unconjugated at 100 µL per vial, the reagent is validated for western blot and immunohistochemistry workflows, supporting detection of endogenous GPR171 protein in research samples. Reactivity is confirmed for human tissue, making it suited to studies examining the GPR171/PSAP/GPR37 receptor complex in neural and metabolic contexts.

Storage at -20 °C in working aliquots is recommended to preserve activity across multiple freeze-thaw cycles; researchers typically dilute the antibody in an appropriate blocking or incubation buffer before each application. The unconjugated format allows flexible pairing with secondary reporters chosen to match the experimental readout, whether chromogenic, fluorescent, or chemiluminescent. Investigators studying central nervous system signaling, appetite regulation, and orphan receptor pharmacology rely on this reagent to characterize GPR171 expression patterns and downstream signaling pathways in cell- and tissue-based assays.