Anti-GPR17 Antibody

The Antibodies.com rabbit polyclonal reagent targets the G protein-coupled receptor GPR17, a purinergic-related receptor implicated in oligodendrocyte differentiation and central nervous system myelination. Raised in rabbit and supplied as an unconjugated polyclonal preparation at 1 mg/ml in PBS buffer with 0.1% sodium azide and 50% glycerol, this antibody supports Western blot and immunofluorescence workflows.

Validated on human, mouse, and rat samples, the reagent ships in a 100 µl volume and is intended for research on purinergic signaling, glial cell biology, and injury responses such as cerebral ischemia. The glycerol-rich formulation permits storage at -20 °C and tolerates standard freeze-thaw cycles, while the azide-containing buffer preserves antibody activity during routine immunodetection.

GPR17 functions as a dualistic receptor responsive to both uracil nucleotides and cysteinyl-leukotrienes, and is widely studied in oligodendrocyte progenitor cells, neurons, and renal epithelium. Researchers applying this reagent in immunofluorescence on tissue sections can map receptor distribution in brain and kidney regions where GPR17 transcripts have been documented. For Western blot, the polyclonal format provides multi-epitope recognition, supporting consistent detection across human and rodent orthologues in cell culture and tissue-based experimental systems.