Anti-GP1BB Antibody

From Antibodies.com, this rabbit polyclonal IgG antibody targets the platelet glycoprotein Ib beta chain (GP1BB), the disulfide-linked subunit of the GPIb-IX-V receptor complex that mediates platelet adhesion to von Willebrand factor at sites of vascular injury. Raised in rabbit and supplied as an unconjugated reagent, the antibody is validated for Western blot (WB) detection of GP1BB in human, mouse, and rat samples, supporting studies of megakaryocyte differentiation, thrombus formation, and Bernard-Soulier syndrome, the rare autosomal-recessive bleeding disorder caused by loss-of-function variants in GP1BB.

Researchers investigating hemostasis and platelet signaling use this reagent to probe receptor expression on the platelet membrane and to track GPIb complex assembly. The format is a 100 µl vial of liquid antiserum applied in standard immunoblotting workflows. Aliquot the reagent on receipt and keep frozen, minimizing freeze-thaw cycles to preserve antibody activity across multiple experiments.