Anti-GNB5 Antibody

Targets the Gβ5 subunit encoded by GNB5, a non-canonical member of the heterotrimeric G-protein β family that preferentially forms obligate dimers with RGS proteins such as RGS6, RGS7, RGS9, and RGS11 rather than classical Gγ subunits. This unusual pairing makes Gβ5 a critical regulator of GTP hydrolysis on Gα subunits and a modulator of GPCR signaling kinetics in neurons and photoreceptors. Loss-of-function variants in GNB5 have been linked to intellectual disability, speech apraxia, and cardiac conduction disease, raising research interest in expression across brain, retinal, and cardiac tissue.

Validated applications include Western blot for protein-level detection in cell and tissue lysates and immunohistochemistry for localization studies in fixed tissue sections. The unconjugated format gives flexibility over secondary antibody choice and detection chemistry, and the polyclonal profile offers broader epitope coverage than monoclonal reagents when probing native Gβ5 complexes. From Antibodies.com, this reagent is raised in rabbit and shows confirmed reactivity against human antigen.

Supplied as 100 µl of liquid in a vial. Store frozen in small aliquots to limit freeze-thaw cycles and preserve titer. For research use only.