Anti-GNB1 Antibody

GNB1, the beta-1 subunit of heterotrimeric G proteins central to transmembrane signal transduction, is the target of this rabbit polyclonal primary antibody from Antibodies.com. Raised in rabbits against a GNB1-derived immunogen, the unconjugated reagent is supplied as 100 µl of a 1 mg/ml stock prepared in PBS with 0.1% sodium azide and 50% glycerol. The glycerol-based buffer permits storage at -20°C in working aliquots to minimize freeze-thaw cycles.

Validated for Western blot (WB) and immunohistochemistry (IHC) workflows, the antibody recognizes GNB1 from human, mouse, and rat samples, supporting cross-species comparative studies of receptor-coupled signaling. Investigators examining G-protein-coupled receptor (GPCR) pathways, beta-adrenergic signaling cascades, or neurodevelopmental disorders linked to GNB1 sequence variants can apply the antibody to detect endogenous protein in cell lysates and fixed tissue sections. The polyclonal format recognizes multiple epitopes on the target, helping maintain signal in experiments where post-translational modification or partial denaturation may otherwise limit detection.