Anti-GNAS Antibody

The Anti-GNAS polyclonal antibody from Antibodies.com is a research reagent raised in a rabbit host and supplied as an unconjugated solution of 100 µl. It specifically recognizes the GNAS protein, the alpha subunit of the stimulatory G protein (Gsα) that couples transmembrane receptors to adenylyl cyclase and drives cyclic AMP signaling downstream of hormones and neurotransmitters.

Validated for Western blot (WB) and immunohistochemistry (IHC) workflows with confirmed reactivity against human, mouse, and rat samples, this reagent supports cross-species studies in endocrinology, oncology, and G protein-coupled signal transduction. Researchers commonly apply it to investigate Gsα expression and activity in tissues affected by GNAS-related disorders, including fibrous dysplasia, McCune-Albright syndrome, and pseudohypoparathyroidism, where activating or inactivating mutations alter receptor-effector coupling and downstream cAMP production.

As a polyclonal antibody, it binds multiple epitopes on the GNAS protein, which can improve signal robustness across denaturing and partially native assay conditions. The unconjugated format gives users flexibility to pair it with their preferred secondary antibody or affinity tag (HRP, biotin, Alexa Fluor, or other fluorophores) matched to the chosen detection system. For best results, aliquot upon first thaw and avoid repeated freeze-thaw cycles to preserve antibody titer across multiple experiments.