Anti-GNAO1 Antibody

The GNAO1 protein (G Protein Subunit Alpha O1) is the alpha subunit of the heterotrimeric Go GTP-binding complex, predominantly expressed in neural tissue where it regulates neurotransmitter release, calcium channel activity, and downstream signaling cascades. This polyclonal antibody from Antibodies.com is raised in rabbit and supplied as 100 µl of unconjugated whole antiserum, suitable for Western Blot (WB) and Immunohistochemistry (IHC) workflows on human and mouse samples. Researchers studying GNAO1-related neurodevelopmental disorders—including early infantile epileptic encephalopathy type 17 (EIEE17) and movement disorder syndromes—use this reagent to map Go-alpha expression in brain sections and to confirm protein levels in lysates from transfected cell lines or patient-derived material. The polyclonal format offers multiple epitope coverage, which can help when detecting splice variants or mutant forms of the target. Store refrigerated and avoid repeated freeze-thaw cycles to preserve antibody activity.