Anti-GNA13 Antibody

This polyclonal antibody from Antibodies.com targets GNA13 (Guanine Nucleotide-Binding Protein Subunit Alpha-13), a heterotrimeric G-protein alpha subunit involved in transmembrane signaling cascades downstream of G protein-coupled receptors. The reagent is raised in rabbit and validated for Western blot (WB) and immunohistochemistry (IHC) workflows, with confirmed reactivity against human, mouse, and rat samples.

Supplied as 100 µl of unconjugated antibody at 1 mg/ml in PBS buffer containing 0.1% sodium azide and 50% glycerol, this format is frequently used by researchers studying RHO-mediated cytoskeletal remodeling, endothelial permeability, and germinal center B-cell signaling. GNA13 has emerged as a recurrently mutated gene in Burkitt lymphoma and other germinal center-derived B-cell lymphomas, where it normally couples lysophospholipid and chemokine receptors to RHOA activation, controlling cell migration and adhesion.

Aliquot upon receipt and store at -20°C to preserve activity; the glycerol-containing formulation helps protect against freeze-thaw damage. The polyclonal format provides recognition of multiple epitopes across the target, supporting consistent detection in tissue sections and immunoblotting of cell lysates from relevant cell lines or primary samples.