Anti-GNA13 Antibody

Rabbit polyclonal affinity reagents are practical tools for interrogating G protein-coupled receptor (GPCR) signaling, and this unconjugated IgG from Antibodies.com targets GNA13, the α-subunit of a heterotrimeric G protein that couples receptor activation to Rho-family GTPases and downstream cytoskeletal remodeling. The reagent ships as a 100 µl volume compatible with western blot, immunohistochemistry, and immunofluorescence workflows, with the unconjugated format leaving fluorophore and enzyme labeling choices to the individual laboratory protocol.

Reactivity has been demonstrated against human, mouse, and rat samples, allowing direct cross-species comparison of GNA13 expression on a single antibody lot. Investigators working on vascular biology, lymphocyte trafficking, and tumor cell invasion use this reagent to map how the GNA13-p115 RhoGEF (ARHGEF1) axis shapes cytoskeletal dynamics, Rho-mediated stress fiber formation, and invasive migration in their system. Because multiple epitopes are recognized by the polyclonal reagent, denatured lysates in WB and fixed tissue sections in IHC both perform well, where conformational epitopes are frequently lost. For storage, refrigerate the vial at 4 °C, protect from light, and prepare single-use aliquots on first thaw to limit freeze-thaw cycles; pair with a verified GNA13-expressing positive-control lysate during initial optimization.