Anti-GNA11 Antibody

This polyclonal antibody from Antibodies.com targets GNA11, the gene encoding the alpha-11 subunit of heterotrimeric G proteins (Gα11), a member of the Gq family that couples cell-surface receptors to phospholipase C-β and downstream calcium signaling. Raised in rabbit and supplied unconjugated in a 100 µl volume, the reagent is validated for Western blot (WB) and immunohistochemistry (IHC) workflows, with confirmed reactivity against human, mouse, and rat samples.

Gα11 is broadly expressed in epithelial, neural, and hematopoietic tissues and contributes to signaling cascades downstream of Gq-coupled receptors. Researchers apply this reagent to probe receptor-driven MAPK and calcium responses, to characterize melanoma-associated pathway mutations, and to study endocrine and vascular signaling where Gα11 and its close paralog Gαq have overlapping or compensatory roles. The polyclonal format provides multi-epitope recognition, supporting detection of full-length protein in lysate-based immunoblots and antigen retrieval-compatible tissue sections.

Recommended applications include immunoblotting of cell and tissue homogenates for endogenous expression profiling and IHC on formalin-fixed, paraffin-embedded sections for localization studies. The unconjugated format allows end-users to couple the antibody to a preferred fluorophore, biotin, or enzyme reporter, and the 100 µl pack size supports small-to-mid-scale experimental panels across multiple targets without excess waste.