Anti-GNA11 Antibody

This rabbit polyclonal antibody targets GNA11, the alpha-11 subunit of heterotrimeric G proteins that couples GPCR signaling to downstream phospholipase C activation and intracellular calcium release. Produced by Antibodies.com as an unconjugated primary reagent in a 100 µl volume, the antibody supports Western blot detection of GNA11 across human and mouse samples, with validated application in immunohistochemistry for localizing the protein in tissue sections. The target itself is of substantial research interest: activating somatic mutations in GNA11 are recurrent drivers of uveal melanoma, while germline variants underlie familial hypocalciuric hypercalcemia type 2 (FHH2) and contribute to pigmentary phenotypes such as those seen in phakomatosis pigmentovascularis. In melanocytes, Gα11 transduces MC1R signaling, connecting G-protein activity to pigmentation pathways. Host species is rabbit, supplied as a polyclonal reagent for both denaturing immunoblotting and fixed-tissue chromogenic or fluorescent staining workflows. Aliquoting upon receipt is recommended to limit freeze-thaw cycles and preserve antibody activity for repeated use.