Anti-glyoxalase I Antibody

Raised in rabbit against the glyoxalase I enzyme, this unconjugated polyclonal antibody from Antibodies.com targets a cytosolic zinc metalloenzyme that catalyzes the conversion of the methylglyoxal–glutathione hemithioacetal into S-D-lactoylglutathione, a key step in methylglyoxal detoxification and the cellular defense against advanced glycation end products (AGEs). Supplied as 100 µL of liquid antiserum in a single vial, the reagent supports Western blot, immunohistochemistry, and immunofluorescence workflows on human specimens, with reactivity confirmed against human glyoxalase I (also known as GLO1 or lactoylglutathione lyase). The unconjugated format gives researchers flexibility to pair it with a secondary reagent of their choice, including HRP-labeled anti-rabbit IgG for chemiluminescent Western blot or fluorophore-conjugated secondaries for multiplex immunofluorescence imaging. Investigators working on diabetic complications, oxidative stress, cancer metabolism, or age-related protein modification apply glyoxalase I antibodies to monitor expression changes, subcellular localization, and tissue distribution patterns relevant to glyoxal-driven pathophysiology. For storage, refrigerate the vial upon arrival, aliquot to limit freeze-thaw cycles, and keep working stocks cold to preserve antibody activity. For research use only.