Anti-GluR4 Antibody

GluR4 (also called GRIA4) is an AMPA-selective glutamate receptor subunit that forms ligand-gated ion channels mediating fast excitatory synaptic transmission in the central nervous system. This rabbit polyclonal reagent from Antibodies.com is raised against the receptor and reactive with human, mouse, and rat samples.

Validated for Western blot and immunohistochemistry, the unconjugated primary antibody is supplied as 100 µL of stock in a vial, supporting immunoblotting of membrane-enriched fractions and IHC localisation of GluR4 expression in neuronal and glial tissue. Polyclonal recognition of multiple epitopes enables detection of the full-length receptor and edited splice variants found in hippocampus, cerebellum, and cortex.

Neuroscience researchers use this reagent to study AMPA receptor trafficking, synaptic plasticity, long-term depression, and excitotoxic injury in models of ischemia, traumatic brain injury, and neurodegenerative disease. The rabbit IgG host isotype allows secondary detection with standard anti-rabbit HRP, alkaline phosphatase, or fluorophore conjugates.