Anti-GluR2 / 3 Antibody

Ionotropic AMPA glutamate receptors assembled from GluR2 and GluR3 subunits carry the bulk of fast excitatory transmission in the central nervous system, and changes in their expression, RNA editing at the Q/R site, and surface trafficking are widely studied in models of ischemia, neurodegeneration, and synaptic plasticity. This Rabbit polyclonal antibody from Antibodies.com was raised against GluR2 and cross-reacts with the closely related GluR3 subunit, making it useful for tracking AMPA receptor pools in neuronal tissue as well as heterologous expression systems.

Supplied unconjugated in a 100 µl volume and validated for western blot and immunohistochemistry workflows, the reagent reacts with Human, Mouse, and Rat samples. The polyclonal format expands the range of epitopes recognised on each subunit, which is an advantage when probing heteromeric receptor complexes or when target abundance is low.

Because no fluorophore or enzyme is pre-conjugated, investigators can pair the antibody with their own choice of secondary reporter — biotin, HRP, or a fluorescent dye — for flexible detection in immunoblotting, fixed-tissue staining, and related immunolabelling protocols.