Anti-GluR-1 Antibody

GluR-1 is the pore-forming subunit of AMPA-type ionotropic glutamate receptors, the principal mediators of fast excitatory synaptic transmission in the central nervous system. This unconjugated rabbit polyclonal antibody from Antibodies.com is raised against the GluR-1 target and is supplied as 100 µl of reagent for laboratory use.

Validated applications include Western blot, immunohistochemistry, immunofluorescence, and ELISA. The reagent shows reactivity against human, mouse, rat, and monkey samples, supporting cross-species studies that bridge rodent disease models with primate tissue experiments.

In practice, the antibody is used to map AMPA receptor distribution across hippocampal and cortical circuits by immunohistochemistry, while Western blot and immunofluorescence workflows support investigations of subunit trafficking during long-term potentiation and other forms of synaptic plasticity tied to learning and memory research. Researchers studying neurodegenerative disease, ischemic injury, and epileptiform activity rely on GluR-1 detection to monitor excitatory synapse integrity under experimental perturbations.