Anti-GLU2B Antibody

The Anti-GLU2B Antibody from Antibodies.com is a rabbit polyclonal reagent raised against the GluN2B subunit (also called NR2B) of the NMDA receptor. It is supplied as 100 µl of unconjugated antisera and has been validated for Western blot and immunofluorescence workflows against human and mouse samples.

This primary antibody supports neuroscience research into glutamatergic signaling, excitatory neurotransmission, and synaptic plasticity. GluN2B-containing NMDA receptors are densely expressed in the forebrain, hippocampus, and cerebral cortex, where they drive learning, memory formation, and developmental synapse maturation. Investigators use the reagent to track receptor trafficking, monitor subunit composition changes in disease models, and study phosphorylation-dependent regulation of the GRIN2B-encoded channel.

The polyclonal format provides broader epitope coverage than a monoclonal reagent, which is helpful when probing post-translational modifications or detecting splice variants. Because the antibody is unconjugated, it can be paired with fluorophore-, biotin-, or enzyme-labeled secondaries to suit individual experimental designs. Confirmed reactivity spans human and mouse targets, making it suitable for work with standard cell lines, primary neuron cultures, and rodent tissue sections.

For handling, aliquot upon receipt to minimize freeze-thaw cycles and store refrigerated; protect from light when using fluorescent secondaries. Researchers commonly apply this reagent to models of Alzheimer's disease, schizophrenia, epilepsy, and ischemic stroke, where altered GluN2B signaling has been implicated.