Anti-GLRB Antibody

This polyclonal antibody from Antibodies.com specifically targets the human glycine receptor beta subunit (GLRB), a ligand-gated chloride channel embedded in neuronal membranes of the central nervous system. Raised in rabbits and purified as an IgG preparation, the reagent is supplied unconjugated in a 100 µl volume suited to western blot workflows investigating inhibitory glycinergic signaling.

Researchers studying startle disorders and related neurological conditions use GLRB-directed antibodies to characterize expression patterns in tissue lysates. Mutations in the gene encoding this subunit are implicated in hyperekplexia, and tracking protein abundance in patient-derived samples versus controls remains a common application. The unconjugated format supports flexible downstream detection, allowing laboratories to pair the primary reagent with their preferred HRP- or fluorophore-labeled secondary antibodies.

Validated for human reactivity, the antibody is appropriate for research use only studies probing the role of glycinergic inhibition in motor circuits, spinal cord physiology, and synaptic transmission. The polyclonal nature of the reagent increases the likelihood of recognizing multiple epitopes on the target protein, which can be advantageous when working with denatured samples on western blots.