Anti-GLRA1 Antibody

Generated in rabbit as an unconjugated polyclonal reagent, this Antibodies.com primary antibody recognizes the glycine receptor subunit alpha-1 (GLRA1), the ligand-gated chloride channel responsible for fast inhibitory neurotransmission in the spinal cord, brainstem, and other central neurons. Mutations in GLRA1 are a well-characterized cause of hereditary hyperekplexia, making the protein a frequent target in neurophysiology, neurogenetics, and ion-channel pharmacology studies.

Each 100 µl vial is validated for Western blot (WB) and immunohistochemistry (IHC) workflows and has been confirmed to react with Human, Mouse, and Rat samples. Polyclonal reactivity across these species makes the reagent useful in comparative studies of glycinergic signaling in rodent models and in archived human tissue specimens.

Recommended handling includes a brief spin before opening, aliquoting to limit repeated freeze-thaw cycles, and storage at the temperature specified on the accompanying data sheet. For Western blot, lysates of brain or spinal cord tissue yield the strongest signal, while IHC workflows benefit from perfusion-fixed sections prepared with standard antigen-retrieval protocols.

Laboratories investigating inhibitory circuit development, startle-disease mechanisms, and postsynaptic receptor localization rely on this reagent to map GLRA1 expression at the membrane of central neurons. Lot-specific validation data ship with each vial from Antibodies.com to support reproducibility across experiments.