Anti-GLO1 Antibody

This polyclonal reagent from Antibodies.com targets GLO1 (Glyoxalase 1), a cytosolic enzyme that catalyzes the conversion of methylglyoxal to D-lactate through the glyoxalase pathway. GLO1 plays a central role in cellular detoxification of reactive carbonyl species generated as byproducts of glycolysis, and it has been investigated in contexts including diabetes, cancer metabolism, oxidative stress, and aging research.

Antibodies.com produces this antibody as a rabbit polyclonal, unconjugated, supplied at 1 mg/mL in PBS with 0.1% sodium azide and 50% glycerol. The product is packaged as a 100 µl vial, suitable for multiple western blot and immunohistochemistry runs depending on dilution. Validated applications include WB and IHC, with reactivity confirmed against human, mouse, and rat samples.

The unconjugated format allows researchers to conjugate the antibody to their preferred reporter, fluorophore, or enzyme for custom assay development. Studies of methylglyoxal metabolism, advanced glycation end products (AGEs), and metabolic disease pathways frequently rely on GLO1 detection. The polyclonal nature of the reagent enables recognition of multiple epitopes on the target protein, which can strengthen signal in applications where the antigen is partially denatured.