Anti-GLA Antibody

Alpha-galactosidase A is the lysosomal hydrolase whose deficiency drives Fabry disease, and this unconjugated rabbit polyclonal reagent from Antibodies.com provides a tool for tracking the enzyme across human, mouse, and rat samples. The antibody is supplied at 100 µl and is validated for Western blot (WB) and immunofluorescence (IF), enabling direct comparison of GLA expression in patient-derived cells, iPSC-derived cardiomyocytes, renal biopsies, and matched mouse tissues.

Because the reagent is polyclonal, it recognizes multiple epitopes on both the GLA precursor and its mature lysosomal form, which is useful when characterizing missense or truncation variants that alter protein stability or processing. Researchers studying enzyme replacement therapy, substrate clearance of globotriaosylceramide (Gb3/GL-3), and X-linked inheritance patterns use it to assess residual protein levels in treated versus untreated fibroblasts, lymphoblasts, and podocyte models.

The unconjugated format leaves the choice of secondary label open, so the same lot can be paired with HRP, Alexa Fluor, or biotinylated secondaries depending on whether the workflow calls for chemiluminescent Western blot imaging or fluorescent IF imaging on fixed cells and tissue sections.