Anti-GJB6 Antibody

This rabbit-derived polyclonal reagent from Antibodies.com recognizes GJB6, the gap junction protein also known as Connexin 30. The target is a transmembrane channel subunit expressed in cochlear epithelium, epidermis, and other tissues where direct intercellular communication is required, making it relevant to studies of hereditary hearing loss variants and Clouston syndrome. The unconjugated IgG preparation is supplied as 200 µl in a vial, validated specifically for Western blot detection of the human antigen.

Because GJB6 is investigated in contexts ranging from DFNB1 and DFNA3 deafness genetics to keratinocyte differentiation and gap junction assembly, the polyclonal format offers broader epitope coverage than a single monoclonal, improving recovery of signal from post-translationally modified or alternatively spliced forms. On Western blots of whole-cell or membrane-enriched lysates, the antibody detects the connexin 30 band in the 30 kDa region. Aliquot the vial on receipt to limit freeze-thaw cycles and store at -20 °C in working volumes to preserve affinity across multi-month projects.