Anti-GJB4 Antibody

Raised in rabbit and supplied as 100 µl of unconjugated antiserum, this polyclonal reagent from Antibodies.com recognizes gap junction protein beta 4 (Connexin 30.3), a connexin family member expressed in keratinocytes and other tissues. It is validated for Western blot (WB) and immunohistochemistry (IHC) workflows and cross-reacts with human and mouse samples. GJB4 is a research target in studies of epidermal gap junction communication and inherited keratinization disorders such as erythrokeratodermia variabilis, where mutations in the GJB4 gene alter channel function. Researchers studying connexin trafficking, skin barrier biology, or auditory and epidermal signaling pathways can use this reagent to detect endogenous Connexin 30.3 in cell lysates by WB or to localize the protein in fixed tissue sections by IHC. The polyclonal format offers recognition of multiple epitopes across the target, supporting robust signal in samples where single-clone antibodies may give weaker or more variable staining. Storage and handling follow standard polyclonal antibody practice: aliquot upon arrival to limit freeze-thaw cycles, store refrigerated for short-term use or frozen for longer-term stability, and protect the vial from light. The product is intended for research use only.