Anti-GIP Antibody

This rabbit-derived polyclonal reagent from Antibodies.com targets Glucose-Dependent Insulinotropic Polypeptide (GIP), a 42-amino acid incretin hormone released by enteroendocrine K-cells of the upper gastrointestinal tract in response to nutrient ingestion. Provided as 100 µL of unconjugated antisera, the reagent is validated for Western blot and immunohistochemistry workflows on human tissue sections and lysates, supporting studies into incretin signaling, postprandial insulin secretion, and the role of GIP in type 2 diabetes, obesity, and gastrointestinal physiology research.

As a polyclonal reagent raised in rabbit, the antibody recognizes multiple epitopes across the mature GIP sequence, which can be advantageous when probing denatured targets on membranes or fixed specimens. Researchers commonly apply it to map GIP expression in pancreatic islets, duodenal biopsies, and adipose tissue, and to investigate crosstalk between GIP and GLP-1 pathways. Unconjugated formulation allows flexible secondary antibody pairing and downstream detection chemistries, including chromogenic IHC and chemiluminescent Western blot. Storage and handling recommendations from Antibodies.com include aliquoting upon receipt to limit freeze-thaw cycles and protecting the vial from light when not in use.