Anti-GGH Antibody

This polyclonal antibody from Antibodies.com targets human gamma-glutamyl hydrolase (GGH), a lysosomal enzyme that cleaves poly-gamma-glutamyl tails from folate derivatives and antifolate drugs such as methotrexate. Raised in rabbit and supplied as an unconjugated 100 µl aliquot, the reagent is validated for Western Blot (WB) and Immunofluorescence (IF) workflows and detects the endogenous human protein. In the published literature, altered GGH expression has been linked to antifolate resistance in tumor cell models, making this antibody a useful reagent for folate metabolism studies, cellular pharmacology investigations, and enzyme-level characterization in cancer research specimens. The polyclonal format allows multi-epitope recognition of the GGH target, supporting reproducible signal in whole-cell lysates and fixed cultured cells across both validated applications.