Anti-GFAP Antibody - Identical to Abcam (ab4674)

Antibodies.com provides a chicken polyclonal antibody to GFAP, raised in chicken and of IgY isotype. The unconjugated reagent is supplied as a liquid and is validated for Western blot (WB), immunohistochemistry (IHC) and immunocytochemistry/immunofluorescence (ICC/IF). It reacts with human, horse, cow, porcine, rat and mouse samples and is cited in one publication.

The target, glial fibrillary acidic protein (GFAP), is relevant to studies of focal white matter lesions, which occur in most neurodegenerative disorders. Research associated with this antibody used a focal white matter lesion in the rat brain within a clinically relevant, anatomically well-defined circuit to show that these lesions evoke transient neuronal activity changes and microgliosis, with subsequent synapse loss and increased microglial engulfment in the grey matter, an effect reversed if myelin regeneration completes. Grey matter microgliosis, often considered detrimental, is shown to be an integral part of regeneration and is conserved across three distinct mouse circuits and lesioning methods. The findings reveal a form of regenerative plasticity coupling white matter integrity to grey matter function, which may underlie multiple neurodegenerative conditions, and highlight the potential of targeting myelin regeneration to prevent chronic neuroinflammation.