Anti-Germ Cell-Specific Antigen Antibody [TRA98]

The TRA98 monoclonal antibody, raised in a rat host, selectively recognizes a nuclear antigen restricted to germ cells across multiple developmental stages — from primordial germ cells through spermatogonia, spermatocytes, and round spermatids. Supplied by Antibodies.com as a 100 µg liquid formulation in an IgG2a format, this unconjugated reagent produces crisp nuclear staining in mouse reproductive tissue, making it a widely cited marker for tracking germ cell lineage in the testis and fetal gonad. Validated applications include Western blot (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry on both frozen (IHC-Fr) and paraffin-embedded (IHC-P) sections. Store frozen at -20°C in small aliquots to limit freeze-thaw cycles, and protect from light when used in fluorescent workflows. Researchers routinely deploy TRA98 to identify spermatogonial stem cells, profile germ cell tumor models such as seminoma and teratoma, and confirm successful germline-competent cell derivation in pluripotent stem cell cultures.