Anti-GCSm-γ Antibody

Raised in rabbit, this polyclonal primary antibody from Antibodies.com targets GCSm-γ (also known as GCLM, the modifier subunit of glutamate-cysteine ligase), the regulatory subunit of the rate-limiting enzyme in glutathione biosynthesis. The unconjugated reagent is supplied as a 100 µl volume and is validated for western blot, immunohistochemistry, and ELISA workflows.

Cross-reactivity has been confirmed against human, mouse, rat, and monkey samples, supporting comparative studies in cell culture and tissue sections that probe redox homeostasis, oxidative stress responses, and phase II detoxification pathways. The polyclonal format provides multiple epitope recognition across denaturing gel conditions and fixed specimen preparations.

Researchers commonly pair this reagent with the corresponding catalytic subunit (GCSm-α / GCLC) antibody to dissect changes in the full heterodimeric ligase complex under conditions such as Nrf2 pathway activation, xenobiotic challenge, or glutathione depletion studies.