Anti-GCLM Antibody

GCLM (glutamate-cysteine ligase modifier subunit) is the regulatory partner of the rate-limiting enzyme that controls cellular glutathione biosynthesis. The Antibodies.com Anti-GCLM Antibody is a rabbit polyclonal primary reagent raised against the human protein for research use only, supplied unconjugated as a 100 µl vial aliquot.

Validated for Western blot (WB) and immunohistochemistry (IHC) workflows, the reagent enables detection of endogenous GCLM in cell lysates and tissue sections from human samples. Because GCLM modulates the activity of the GCLC catalytic subunit, the antibody supports studies of oxidative stress, redox homeostasis, and disease contexts including neurodegeneration, cardiovascular disorders, and cancer chemoresistance.

This polyclonal antibody recognizes multiple epitopes on the GCLM protein, producing a robust signal for protein-level analysis. For long-term use, aliquot the reagent upon receipt and store frozen, avoiding repeated freeze-thaw cycles to preserve binding activity.