Anti-GCH1 Antibody

This rabbit polyclonal IgG antibody from Antibodies.com targets GCH1 (GTP cyclohydrolase 1), the rate-limiting enzyme that initiates tetrahydrobiopterin (BH4) biosynthesis and supports downstream production of dopamine, serotonin, and nitric oxide. Provided as 100 µl of unconjugated antiserum validated for Western blot detection of human GCH1 protein, the reagent enables researchers investigating neurotransmitter metabolism, neuropathic pain signaling, and inherited disorders such as DOPA-responsive dystonia and autosomal dominant hyperphenylalaninemia. Polyclonal specificity allows recognition of multiple epitopes across the target, while the unconjugated format permits flexible pairing with HRP, fluorophore, or biotin secondary detection chemistries. Aliquot upon first use and store refrigerated to preserve antibody activity across repeated experiments; avoid repeated freeze-thaw cycles that can degrade immunoglobulin performance.