Anti-GCH1 Antibody

Raised in Rabbit against GTP cyclohydrolase 1 (GCH1), this unconjugated polyclonal primary antibody is supplied by Antibodies.com at a 100 µl volume and validated for western blot and immunohistochemistry on human samples. GCH1 is the rate-limiting enzyme that initiates tetrahydrobiopterin (BH4) biosynthesis, supplying the essential cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, and nitric oxide synthases. Because of this central metabolic role, the target is widely studied in dopaminergic neuron biology, vascular nitric oxide signaling, and inherited disorders linked to BH4 deficiency, including autosomal dominant DOPA-responsive dystonia (Segawa syndrome). The unconjugated format leaves secondary antibody pairing and detection chemistry fully open to the user, making the reagent suitable for both chemiluminescent western blot readout of whole-cell lysates and chromogenic or fluorescent IHC staining of fixed tissue sections. Host species, clonality, and conjugation status are matched to standard immunodetection workflows that compare control versus patient or treated samples, and the reagent ships as part of the Antibodies.com Primary Antibodies catalog for laboratory research use.