Anti-GBP5 Antibody

This rabbit polyclonal antibody from Antibodies.com targets human Guanylate-Binding Protein 5, an interferon-inducible GTPase central to innate immune defense. The unconjugated reagent is supplied at 100 µl per vial and is validated for Western blot and immunohistochemistry on human samples, supporting studies of cell-autonomous immunity and host-pathogen interactions.

GBP5 is a dynamin-like GTPase of the guanylate-binding protein family that is strongly upregulated by type I and type II interferons and contributes to antibacterial defense against intracellular pathogens such as Listeria monocytogenes and Mycobacterium tuberculosis, as well as to NLRP3 inflammasome assembly and the regulation of autophagy and pyroptosis. The polyclonal format offers multi-epitope recognition for reliable detection in immunoblotting and chromogenic staining workflows, and the antibody is specific to human GBP5. For storage, refrigerate the vial upon arrival, protect from light, and aliquot to limit freeze-thaw cycles of the working stock.