Anti-GBP1 Antibody

Primary antibodies against guanylate-binding protein 1 support research into interferon-driven innate immunity and cellular host defense. GBP1 is an IFN-induced GTPase of roughly 67 kDa that helps cells resist intracellular bacteria and parasites, and it is widely used as a readout of interferon signaling in inflammation, infection, and auto-inflammatory studies. This rabbit polyclonal reagent from Antibodies.com is raised against human GBP1 and supplied as 100 µL of unconjugated antiserum suitable for western blot analysis of cell lysates and immunofluorescence labeling of fixed cells or tissue sections. Investigators tracking GBP1 induction across IFN-α, IFN-β, and IFN-γ stimulation time courses in macrophages, epithelial lines, and primary immune cells rely on this reagent to follow endogenous expression dynamics. The polyclonal format increases tolerance for epitope variation across isoforms and post-translational modifications, while the unconjugated format allows free pairing with fluorophore- or HRP-labeled secondary antibodies chosen for a specific imaging or blotting system.