Anti-GBP1 Antibody

Produced in rabbit as an unconjugated polyclonal reagent, this Antibodies.com antibody recognizes human GBP1 (Guanylate Binding Protein 1), a member of the interferon-inducible guanylate-binding protein family that mediates host defense responses to viral and intracellular bacterial pathogens. The 100 µl format supports multiple experimental runs across Western blot and immunohistochemistry workflows on human cells and tissue.

GBP1 transcription is potently induced by type I and type II interferons, and the protein accumulates in the cytoplasm of infected or cytokine-stimulated cells where it participates in inflammasome activation, pathogen vacuole targeting, and antimicrobial effector functions. Investigators track GBP1 expression to probe interferon signaling status, characterize inflammatory infiltrates in fixed tissue sections, and validate infection models in human cell lines. The unconjugated format gives flexibility in choosing secondary antibodies and detection chemistries, including HRP, biotin-streptavidin, or fluorophore-conjugated reporters.

For best results, store frozen at -20°C in small working aliquots to minimize freeze-thaw cycles, and protect the reagent from light. Because the antibody is polyclonal, it recognizes multiple epitopes on the human GBP1 target, which can improve detection in immunohistochemistry where epitope accessibility varies across different tissue preparations. Researchers examining IFN-driven inflammation, host-pathogen interactions, or tumor immune microenvironments will find this reagent a useful tool for discovery-oriented and confirmatory studies alike.