Anti-GAN Antibody

Gigaxonin (GAN) is a BTB-Kelch domain adaptor for Cullin 3-based E3 ubiquitin ligases whose dysfunction causes Giant Axonal Neuropathy, a progressive neurodegenerative disorder that disrupts both the peripheral and central nervous systems. This unconjugated rabbit polyclonal IgG antibody from Antibodies.com is raised against the GAN protein and validated for Western blot detection in human and mouse samples. The 50 µl aliquot is supplied as a ready-to-use reagent suitable for probing gigaxonin expression in neuronal and non-neuronal lysates, supporting research into intermediate filament turnover, ubiquitin-proteasome regulation, and disease-associated variants mapped to chromosome 16q24.1. Investigators studying axonal cytoskeletal organization, Cul3-mediated substrate recognition, or genotype-phenotype correlations in patient-derived samples will find this polyclonal reagent a versatile tool. Storage at -20 °C in working aliquots preserves antibody activity across multiple freeze-thaw cycles.