Anti-GAN Antibody

Gigaxonin (GAN), an E3 ubiquitin ligase encoded by the GAN gene, is the target of this polyclonal antibody raised in rabbit. The unconjugated IgG reagent is supplied as a 200 µl volume and is validated for Western Blot detection of endogenous gigaxonin in human and mouse samples. Mutations in the GAN gene are linked to giant axonal neuropathy, a rare neurodegenerative disorder affecting both the peripheral and central nervous systems, making reliable immunological tools important for studying intermediate filament organization, cytoskeletal dynamics, and disease-associated protein aggregation. Produced by Antibodies.com as part of its Primary Antibodies portfolio, this reagent supports routine immunoblotting workflows in research laboratories exploring neurodegeneration, neurofilament metabolism, and ubiquitin-proteasome pathway function. The host species is rabbit and the antibody is provided without a fluorophore or enzyme label, allowing investigators to pair it with their own preferred secondary detection system. Storage recommendations should follow the manufacturer's instructions to preserve antigen-binding activity across multiple experiments.