Anti-GALNT3 Antibody

GALNT3 is a Golgi-resident glycosyltransferase that initiates mucin-type O-linked glycosylation by transferring N-acetylgalactosamine onto serine and threonine residues of substrate proteins. This rabbit polyclonal Anti-GALNT3 reagent from Antibodies.com is supplied as a 200 µl unconjugated IgG preparation validated for western blot detection of the human target.

GALNT3 has become a focus of biochemical and translational research because it glycosylates the hormone FGF23, a key regulator of renal phosphate excretion, and loss-of-function variants in GALNT3 have been implicated in hyperphosphatemic familial tumoral calcinosis and related disorders of mineral metabolism. Altered GALNT3 expression has also been reported in several cancer settings, where aberrant O-glycosylation contributes to tumor progression and remodeling of the cell-surface proteome.

The polyclonal format makes this reagent useful for detecting full-length GALNT3 as well as naturally occurring isoforms and engineered variants in cell lysates and tissue homogenates, supporting investigations of glycosyltransferase regulation, phosphate homeostasis, and tumor biology. The unconjugated IgG format also permits flexible pairing with secondary antibodies of the researcher's choice for chemiluminescent western blot workflows and downstream detection on different visualization platforms.