Anti-Galectin 3 Antibody

Raised in rabbit as an unconjugated polyclonal reagent, this Antibodies.com primary antibody binds galectin-3, a beta-galactoside-binding lectin implicated in cell-cell adhesion, macrophage activation, angiogenesis, and fibrotic signaling. The immunogen corresponds to the human LGALS3 sequence, and the antibody cross-reacts with the mouse and rat orthologues, supporting comparative studies across common laboratory models. Validated applications include Western blot, immunohistochemistry, and immunofluorescence, allowing detection of endogenous galectin-3 in fixed tissue sections and cultured cells. The antibody is supplied as 100 µl of liquid, unconjugated for direct detection or flexible pairing with secondary reporters of choice.

Galectin-3 is broadly distributed across epithelial and myeloid lineages and is investigated in tumor invasion, cardiac fibrosis, and chronic inflammatory disease, so a reagent that labels the endogenous protein in formalin-fixed samples and on Western membranes is useful for both basic and translational workflows. Researchers commonly employ this antibody to track cytoplasmic and nuclear galectin-3 distribution, monitor expression changes during epithelial-to-mesenchymal transition, and probe the lectin's role in tumor microenvironment signaling.