Anti-GADD 45γ (S123) Antibody

This rabbit polyclonal primary antibody from Antibodies.com recognizes the GADD45γ (Growth Arrest and DNA Damage 45 gamma) protein phosphorylated at serine 123, a post-translational modification associated with the cellular response to genotoxic stress and stress-signal transduction. Raised in rabbit and supplied as an unconjugated IgG preparation at 1 mg/ml in phosphate buffered saline (PBS) with 0.05% sodium azide at approximately pH 7.2, the reagent is provided as 100 µl aliquots and is validated for Western blot (WB) and immunohistochemistry (IHC) applications. Reactivity has been confirmed against human, mouse, and rat samples, supporting comparative studies across standard mammalian model systems used in DNA damage, cell cycle, and tumor biology research. Investigators probing stress-induced gene expression, apoptotic priming, and DNA damage checkpoint signaling can apply the antibody to cell lysates or fixed tissue sections to track S123 phosphorylation dynamics under diverse experimental treatments. The polyclonal format offers affinity-based detection of the modified epitope while retaining tolerance for minor sequence variation between species orthologs. Because the preparation contains sodium azide as a preservative, standard laboratory handling precautions should be observed.