Anti-GAD1 / 2 Antibody

This rabbit polyclonal reagent from Antibodies.com targets GAD1 (glutamic acid decarboxylase 1, the 67 kDa cytosolic isoform also called GAD67), the enzyme that converts L-glutamate into the inhibitory neurotransmitter GABA in central nervous system neurons and pancreatic islet beta cells. The antibody is supplied as 100 µL of unconjugated antiserum in a single vial and has been validated on human and mouse samples for Western blot and immunohistochemistry workflows.

The polyclonal format increases the likelihood of recognizing multiple epitopes on GAD1 and the closely related GAD2 isoform (GAD65), making this Antibodies.com reagent useful for studies of GABAergic signaling, inhibitory synapse biology, and islet cell autoantibody research relevant to type 1 diabetes. Researchers commonly apply it to brain tissue sections and neuronal lysates, where it can reveal somatodendritic GAD67 distribution, and the unconjugated format allows pairing with a user-selected HRP, biotin, or fluorophore secondary reagent of their choice.