Anti-GABRR1 Antibody

Produced in rabbit and validated for Western Blot, this unconjugated polyclonal antibody from Antibodies.com targets GABRR1, the rho-1 subunit of ionotropic GABA-A receptors. Supplied at 1 mg/ml in phosphate buffered saline with 15 mM sodium azide (approximately pH 7.2) and packaged as a 100 µl vial, the reagent detects human, mouse, and rat GABRR1 in Western Blot workflows.

GABRR1 encodes a ligand-gated chloride channel subunit that is most abundantly expressed in retinal bipolar cells and is also present at lower levels in select regions of the central nervous system. Because rho-containing receptors have distinct pharmacological properties from classical GABA-A receptors, including insensitivity to bicuculline, antibodies raised against GABRR1 are widely used in neuroscience and ophthalmology research to map receptor distribution, characterise inhibitory synaptic transmission, and probe retinal circuitry.

As a polyclonal reagent, the antibody recognises multiple epitopes on the GABRR1 subunit, which can improve signal in Western Blot applications where epitope accessibility varies between preparations. Researchers handling this reagent should keep the vial refrigerated for short-term use and freeze working aliquots at -20 degrees C for longer-term storage to limit repeated freeze-thaw cycles. Sodium azide acts as a preservative against microbial contamination and should be handled with appropriate laboratory safety practices.